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KMID : 0378019740170040461
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New Medical Journal
1974 Volume.17 No. 4 p.461 ~ p.470
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Electron Microscopic Observations of Mouse Liver Cell Treated with Fungal Culture Filtrates Isolated from Foodstuffs
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Abstract
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The purpose of present study is to determine the toxicity of several mycotoxin-producing fungi, named A. flavus ATCC 15517, A. parasiticus RIB 1037, A. toxicarium RIB 4002, P. citrinum SWU 238, P. islandicum IFO 5235, P. tardum IFO 5787, and P. brunneum by observing the ultrastructural changes in the mouse liver cells. The results as follows:
1. All of the experimental animals treated with reference strains were observed the focal necrosis and inflammatory infiltration of liver parenchymal cell.
2. It showed cytoplamic changes such as dilatation of endoplasmic reticulum, swelling of mitochondria, detachment of ribosomes, increased number of lipid droplets and glycogens.
3. Nuclear and nucleolar alterations were also noted the nucleolar capping, segregation of nucleolar elements and irregularity of nuclear envelopes.
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KEYWORD
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